This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex I, Linear skin defects with multiple congenital anomalies 3 (LSDMCA3), Mitochondrial complex I deficiency, nuclear type 30 (MC1DN30), Am. NADH dehydrogenase (ubiquinone) Narrower (2) NADH dehydrogenase complex (plastoquinone) respiratory chain complex I location. is extremely low. These are stable identifiers and should be used to cite UniProtKB entries.Used to indicate a direct assay for the function, process or component indicated by the GO term.
[5] Variations in human MT-ND5 are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) as well as some symptoms of Leigh's syndrome and Leber's hereditary optic neuropathy (LHON). I). [4] The ND5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Manual assertion inferred by curator fromi. This protein is part of a large enzyme complex known as complex I, which is active in mitochondria. 2003 Apr 18;278(16):13619-22. The flow of electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. There are a number of rotenone-insensitive NADH dehydrogenases located on the outer and inner surface of the inner mitochondrial membrane in plant and yeast mitochondria. This respiratory entry point affects the amount of ATP produced per NADH/O 2 consumed and therefore impacts the maximum yield of biomass and/or cellular products from a given amount of substrate. (2008) identified a homozygous G-to-A transition in intron 1 of the NDUFA11 gene, resulting in a splice site mutation. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:,This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.
,This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.
, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial,This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.
,This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. Antiaris africanais a plant in Nigeria, generally used for the treatment of nervous disorders. NADH-succinate dehydrogenase is a mitochondria enzyme used as a biomarker of mitochondria integrity. [11] Those with MT-ND5 mutations can display the major features of MELAS and MERRF in some patients, as well as symptoms of Leigh's syndrome and/or Leber's hereditary optic neuropathy (LHON) in others.
What is the canonical sequence?
canonicali sequence. Pyruvate dehydrogenase may be allosterically activated by fructose-1,6-bisphosphate and is inhibited by NADH and acetyl-CoA. Mitochondria are structures within cells that convert the energy from food into a form that cells can use. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.
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